The International Tinnitus Journal

The International Tinnitus Journal

Official Journal of the Neurootological and Equilibriometric Society
Official Journal of the Brazil Federal District Otorhinolaryngologist Society

*Type a word

ISSN: 0946-5448

Abstract

The Role of the Parabrachial Nucleus in the Natural History of Tinnitus and Its Implications

Author(s): Martin L. Lenhardt, Abraham Shulman and Barbara A. Goldstein

The final common pathway in severe tinnitus is modified to include the parabrachial nucleus, which has been identified by cfos immunocytochemistry as an active, nonauditory site. The parabrachial nucleus acts in conjunction with the amygdala and insula (part of the medial temporal lobe system) to produce a somatic emotional sense that can result in a “bad” feeling. The activation of the final common pathway is rapid, suggesting that early treatment is prudent to prevent neuroplastic changes that would likely lessen affect.

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