The International Tinnitus Journal

LOW-MOLECULAR-WEIGHT ANTIOXIDANT THERAPY IN TRAUMATIC BRAIN INJURY AND ACUTE CEREBRAL INSUFFICIENCY ASSOCIATED WITH TINNITUS

Z.F.Ramazanova, N.K.Ibragimov, Z.T.Gaziev, R.S.Muralimova, X.A.Boymurodov, N.Sh.Yusupova, B.Dj.Yusupova

Background: Traumatic brain injury (TBI) is frequently accompanied by acute cerebral insufficiency and a complex cascade of secondary neurological and metabolic disturbances. Oxidative stress plays an important role in the progression of secondary brain injury and may contribute to the development and persistence of tinnitus. Low-molecular-weight antioxidants have the potential to modulate oxidative imbalance and reduce the severity of pathological processes associated with cerebral dysfunction. Objective: To evaluate the clinical and therapeutic significance of low-molecular-weight antioxidant therapy in patients with traumatic brain injury complicated by acute cerebral insufficiency and tinnitus. Methods: The study included patients with traumatic brain injury and clinical manifestations of acute cerebral insufficiency associated with tinnitus. As part of complex treatment, patients received antioxidant therapy based on low-molecular-weight antioxidants. Clinical and neurological status, severity of tinnitus, cerebral functional parameters, and selected biochemical indicators of oxidative stress and antioxidant defense were assessed dynamically during treatment. Particular attention was given to changes in lipid peroxidation and endogenous antioxidant activity. Results: The use of low-molecular-weight antioxidants as part of complex therapy was associated with favorable clinical dynamics, including improvement in neurological status and reduction in the severity of tinnitus. Treatment was accompanied by a tendency toward normalization of oxidative stress-related biochemical parameters and enhancement of antioxidant defense. These findings suggest that correction of oxidative imbalance may contribute to improved cerebral function and clinical recovery in patients with TBI and acute cerebral insufficiency. Conclusion: Low-molecular-weight antioxidant therapy may represent a promising component of the complex management of traumatic brain injury complicated by acute cerebral insufficiency and tinnitus. Its potential benefits may be related to modulation of oxidative stress and restoration of the balance between pro-oxidant and antioxidant mechanisms. Further controlled studies are warranted to clarify the mechanisms underlying the relationship between oxidative stress, cerebral dysfunction, and tinnitus following TBI.