The International Tinnitus Journal


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The International Tinnitus Journal

Official Journal of the Neurootological and Equilibriometric Society
Official Journal of the Brazil Federal District Otorhinolaryngologist Society

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ISSN: 0946-5448


Tinnitus: Pharmacological Topodiagnosis

Author(s): Dario Alpini, Antonio Cesarani, Davide Antonio Giuliano, and Saverio Capobianco

The difficulty of accurately localizing the source of subjective tinnitus is wellknown. Anamnesis and traditional audiological tests can often suggest a source if its origin as peripheral or merely central (or both). Therefore, several authors , such as Risey, Denk, and Shulman, recently proposed identifying the source of subjective tinnitus through the evaluation of the responses reported by patients to adequate pharmacological treatments . Our study presents a useful plan to perform tinnitus topodiagnosis, which consists of specific audiological tests evaluating the characteristics of symptoms (annoyance, pitch, loudness, hyperacusis) and of several pharmacological tests carried out through the administration of particular drugs, the pharmacodynamic mechanisms and meaningful side effects ofwhich are described. On the basis of pharmacological effects on tinnitometry, some drugs will be combined.